MACROPHAGE-ADIPOCYTE CROSS-TALK

Категория: Медико-биологические дисциплины

MACROPHAGE-ADIPOCYTE CROSS-TALK
MACROPHAGE-ADIPOCYTE CROSS-TALK
Автор
Ivy T. Y. Lau
Год выпуска
2010
Издательство
LAP Lambert Academic Publishing
Страниц
124
Наличие
товар закончился
Recent studies suggest that chronic inflammation of adipose tissues with macrophage infiltration and enhanced expression of pro-inflammatory cytokines plays a significant role in the development of obesity-related metablic disorders, such as type 2 diabetes. It was demonstrated that adenovirus- mediated over-expression of adiponectin, an anti- inflammatory insulin-sensitizing adipokine with reduced expression in obesity, resulted in a marked down-regulation of several inflammation-related genes, including F4/80 and CD68 (macrophage markers), and monocyte chemotactic protein-1 (MCP- 1), in the white AT of 12 weeks old db/db diabetic mice. It was hypothesized that the reduced expression of adiponectin might play an important role in initiating macrophage-adipocyte cross-talk which leads to obesity-related insulin resistance and diabetes. This study aimed at determining the time course and magnitude of macrophage infiltration and inflammatory activation in AT, in relation...
Готовые работы схожей тематики
Тема работы Тип работы
Международные мигранты на европейском рынке труда
Экономика
......
Дипломная работа
82 стр. / 10000 руб.
Посмотреть